Cyclic AMP-dependent phosphorylation of a brain inositol trisphosphate receptor decreases its release of calcium

Academic Article


  • We report the stoichiometric phosphorylation of an inositol 1,4,5-trisphosphate receptor-binding protein from rat brain by the cAMP-dependent protein kinase but not by protein kinase C or Ca2+/calmodulin-dependent protein kinase. This phosphorylation event does not markedly alter [3H]inositol 1,4,5-trisphosphate-binding characteristics. However, inositol 1,4,5-trisphosphate is only 10% as potent in releasing 45Ca2+ from phosphorylated, as compared with native, cerebellar microsomes. Phosphorylation of the inositol 1,4,5-trisphosphate-binding protein by the cAMP-dependent protein kinase may provide a biochemical substrate for second-messenger cross talk.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Supattapone S; Danoff SK; Theibert A; Joseph SK; Steiner J; Snyder SH
  • Start Page

  • 8747
  • End Page

  • 8750
  • Volume

  • 85
  • Issue

  • 22