Inositol hexakisphosphate receptor identified as the clathrin assembly protein AP-2

Academic Article


  • To clarify the function of the receptor binding protein for inositol hexakisphosphate (IP6), we obtained a partial amino acid sequence from the purified protein and a partial nucleotide sequence from a cDNA clone of the gene. The sequences are essentially identical to those of the α-subunit of the clathrin assembly protein AP-2. The IP6 receptor protein analyzed by SDS-PAGE contains a series of subunits which are the same as those of AP-2. Antibodies to AP-2 react with the IP6 receptor protein in immunoblot analysis. © 1992 Academic Press, Inc.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Voglmaier SM; Keen JH; Murphy JE; Ferris CD; Prestwich GD; Snyder SH; Theibert AB
  • Start Page

  • 158
  • End Page

  • 163
  • Volume

  • 187
  • Issue

  • 1