Preimplantation genetic diagnosis of Marfan syndrome with the use of fluorescent polymerase chain reaction and the automated laser fluorescence DNA sequencer

Academic Article


  • Objective: To develop and apply clinical preimplantation genetic diagnosis (PGD) for Marfan syndrome. Design: Case report. Setting: Centers for medical genetics and reproductive medicine in university hospitals. Patient(s): One couple in which the husband was affected with Marfan syndrome. Intervention(s): The couple underwent three intracytoplasmic sperm injection cycles. Main Outcome Measure(s): The correct diagnosis was obtained for embryos in three PGD cycles. Result(s): Although all the PGD cycles were followed by ET, no pregnancy ensued. Conclusion(s): This assay can provide a reliable and accurate preimplantation diagnosis of Marfan syndrome.
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    Digital Object Identifier (doi)

    Author List

  • Sermon K; Lissens W; Messiaen L; Bonduelle M; Vandervorst M; Van Steirteghem A; Liebaers I
  • Start Page

  • 163
  • End Page

  • 166
  • Volume

  • 71
  • Issue

  • 1