Targeted radionuclide therapy.

Academic Article

Abstract

  • Targeted radionuclide therapy (TRT) seeks molecular and functional targets within patient tumor sites. A number of agents have been constructed and labeled with beta, alpha, and Auger emitters. Radionuclide carriers spanning a broad range of sizes; e.g., antibodies, liposomes, and constructs such as nanoparticles have been used in these studies. Uptake, in percent-injected dose per gram of malignant tissue, is used to evaluate the specificity of the targeting vehicle. Lymphoma (B-cell) has been the primary clinical application. Extension to solid tumors will require raising the macroscopic absorbed dose by several-fold over values found in present technology. Methods that may effect such changes include multistep targeting, simultaneous chemotherapy, and external sequestration of the agent. Toxicity has primarily involved red marrow so that marrow replacement can also be used to enhance future TRT treatments. Correlation of toxicities and treatment efficiency has been limited by relatively poor absorbed dose estimates partly because of using standard (phantom) organ sizes. These associations will be improved in the future by obtaining patient-specific organ size and activity data with hybrid SPECT/CT and PET/CT scanners.
  • Authors

    Published In

  • Medical Physics  Journal
  • Keywords

  • Anatomy, Auger effect, Cancer, Computed tomography, Conformal radiation treatment, Dosimetry, Medical imaging, Positron emission tomography, Positron emission tomography (PET), Proteins, Single photon emission computed tomography, Single photon emission computed tomography (SPECT), Tissue engineering, Tissues, absorbed dose, alpha-particle sources, antibodies, beta-ray sources, blood, cellular biophysics, positron emission tomography, radiation therapy, radioisotopes, radionuclide therapy, single photon emission computed tomography, tumours
  • Digital Object Identifier (doi)

    Pubmed Id

  • 8386466
  • Author List

  • Williams LE; DeNardo GL; Meredith RF
  • Start Page

  • 3062
  • End Page

  • 3068
  • Volume

  • 35
  • Issue

  • 7Part1