An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer

Academic Article


  • The expression of core 2 β1,6-N-acetylglucosaminyltransferase-1 (C2GnT) is associated with development and progression of malignancy. Sequence analysis showed that the codon 152 of C2GnT has a polymorphism having GTT encoding valine or ATT encoding isoleucine. By examining the polymorphism in prostate cancer and benign prostatic hyperplasia patients, we found that the C2GnT G allele was more frequently observed in the prostate cancer group (p = 0.015) than the control group. Men with the GG genotype had a 3.60-fold increased risk of prostate cancer, and men with the AG genotype had a 1.58-fold increased risk of prostate cancer compared with those with the AA genotype. The G allele was found to have a gene dosage effect for prostate cancer risk. No such risk was associated for benign prostatic hyperplasia. These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population. © 2005 Elsevier Inc. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Wang L; Mitoma J; Tsuchiya N; Narita S; Horikawa Y; Habuchi T; Imai A; Ishimura H; Ohyama C; Fukuda M
  • Start Page

  • 958
  • End Page

  • 963
  • Volume

  • 331
  • Issue

  • 4