Signalling through FOXP3 as an X-linked tumor suppressor.

Academic Article


  • The FOXP3 (forkhead box P3) gene is a member of forkhead winged helix family transcription factors and functions as both a transcriptional activator and a repressor. FOXP3 dysfunction is responsible for an X-linked autoimmune syndrome: immune dysregulation, polyendopathy, enterophathy, X-linked syndrome. In addition to its role as an essential transcription factor in regulatory T cells, the FOXP3 gene is an epithelial cell-intrinsic tumor suppressor for breast and prostate cancers. We will focus on the FOXP3 signalling pathway in epithelial cells and discuss how genetic and/or epigenetic inactivation of the FOXP3 contributes to the malignant transformation of cells.
  • Keywords

  • Animals, Breast Neoplasms, Female, Forkhead Transcription Factors, Genes, Tumor Suppressor, Genes, X-Linked, Humans, Male, Prostatic Neoplasms
  • Digital Object Identifier (doi)

    Author List

  • Katoh H; Zheng P; Liu Y
  • Start Page

  • 1784
  • End Page

  • 1787
  • Volume

  • 42
  • Issue

  • 11