Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary

Academic Article


  • Dehydration significantly reduced the concentration of immunoreactive dynorphin A(1-17), dynorphin A(1-8), α-neo-endorphin, β-neo-endorphin, and leu-enkephalin in the rat pituitary posterior-intermediate lobe. A statistically significant increase in immunoreactive dynorphin A(1-8), α-neo-endorphin and leu-enkephalin was observed in the hypothalamus. Comparison of the molar ratios of dynorphin A(1-17): dynorphin A(1-8) and α-neo-endorphin:β-neo-endorphin showed an altered profile of stored pro-dynorphin cleavage products in the posterior-intermediate lobe of the pituitary of dehydrated rats. © 1985.
  • Published In

  • Life Sciences  Journal
  • Digital Object Identifier (doi)

    Author List

  • Lorenz RG; Evans CJ; Barchas JD
  • Start Page

  • 1523
  • End Page

  • 1528
  • Volume

  • 37
  • Issue

  • 16