Autoimmune gastritis in a murume transgenic model

Academic Article

Abstract

  • Type A or autoimmune gastritis is a gastrointestinal disease in which both humoral and cell-mediated immunity have been postulated to play an essential role. To establish a mouse model of autoimmune gastric disease, we have generated transgenic mice which express a reporter protein exclusively in the parietal cell population of the stomach and are functionally tolerant to this transgenic reporter. We have demonstrated that this tolerance can be ablated by immunization with the reporter protein, resulting in antigen-specific T cell proliferation, antibody production, and altered epithelial architecture in the zymogenic glands of the stomach. This novel model of gastrointestinal autoimmune disease is ideally suited to investigate the relative contributions of immune cell subsets, cytokines and immune mediators to the pathogenesis and maintenance of inflammatory gastric disease.
  • Published In

    Pubmed Id

  • 10585998
  • Author List

  • Chen D; Lorenz R
  • Volume

  • 10
  • Issue

  • 6