This paper presents a review of two years experience regarding senior design projects to aid persons with disabilities, for mechanical engineering students at the University of Alabama at Birmingham (UAB). The efforts are funded by the National Science Foundation and are aimed at developing alternative, low cost, custom devices to aid specific disabled individuals or targeted groups. A collaboration has been established with UAB Occupational Therapy and United Cerebral Palsy of Birmingham (UCP), who have provided projects which combine depth in both engineering and life sciences. The 'UAB experience' described in the following includes project selection, development, student advising and overall significance. Completed designs are listed, along with efforts to bring the products to a marketable level.