Immunoglobulin-based investigation of spontaneous resolution of chlamydia trachomatis infection

Academic Article

Abstract

  • © The Author 2017. Chlamydia trachomatis elementary body enzyme-linked immunosorbent assay (ELISA) was used to investigate serum anti-CT immunoglobulin G1 (IgG1; long-lived response) and immunoglobulin G3 (IgG3; short-lived response indicating more recent infection) from treatment (enrollment) and 6-month follow-up visits in 77 women previously classified as having spontaneous resolution of chlamydia. Of these women, 71.4% were IgG1+IgG3+, consistent with more recent chlamydia resolution. 15.6% were IgG3- at both visits, suggesting absence of recent chlamydia. Using elementary body ELISA, we demonstrated approximately 1 in 6 women classified as having spontaneous resolution of chlamydia might have been exposed to C. trachomatis but not infected. Further, we classified their possible infection stage.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Bakshi RK; Gupta K; Jordan SJ; Brown LDT; Press CG; Gorwitz RJ; Papp JR; Morrison SG; Lee JY; Morrison RP
  • Start Page

  • 1653
  • End Page

  • 1656
  • Volume

  • 215
  • Issue

  • 11