This report summarizes the discussion of a working group assembled by the JHS coordinating center to consider potential hypertension research related to the parent study. The working group reviewed several research hypotheses that could be tested with ongoing follow-up of, and additional study visits for, the JHS cohort. Discussions extended beyond observational followup of enrolled participants and included randomized interventions and the development of a hypertension registry. A summary of potential research opportunities is provided in Table 2.