Longterm effectiveness of herpes zoster vaccine among patients with autoimmune and inflammatory diseases

Academic Article


  • Objective. The protection duration of herpes zoster (HZ) vaccination is unclear among patients with autoimmune (AI) diseases. Methods. Using 2006-2013 Medicare data, HZ vaccinated patients with AI were matched 1:2 to unvaccinated HZ. Incidence rates (IR) and adjusted risk ratios over time were calculated using Poisson regression. Results. Of 59,627 vaccinated patients, crude IR increased from 0.75/100 person-years during the first year post-vaccination to 1.25 during the seventh year. Vaccinated patients had a significantly lower risk of HZ compared with the unvaccinated through 5 years. Conclusion. HZ vaccination was significantly protective only for about 5 years among patients with AI.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Yun H; Xie F; Baddley JW; Winthrop K; Saag KG; Curtis JR
  • Start Page

  • 1083
  • End Page

  • 1087
  • Volume

  • 44
  • Issue

  • 7