Proper nutritional support is essential for optimal therapy in children with cancer. However, because of anorexia secondary to the malignancy or therapy, or because of the location of the tumor (ie, nasopharyngeal carcinoma), malnutrition can become a significant problem in these cancer children. Placement of enteral nutrition ports were performed on 15 children with malignancy using minimal access techniques. There was no perioperative mortality, but leukopenia secondary to chemotherapy was associated with tube site inflammation in seven of the children. Most of these were treated successfully with local wound care and intravenous antibiotics. Overall, minimal access techniques were safe and provided the additional advantages of: screening the abdominal cavity for residual or metastatic disease, performance of concurrent procedures such as biopsy and fundoplication, and allowed for the immediate institution of chemotherapy and radiotherapy.