Effect of magnesium sulfate on eicosanoid levels in women with pregnancy-induced hypertension

Academic Article

Abstract

  • Objective: The mechanism(s) by which magnesium sulfate (MgSO ) functions clinically to prevent eclamptic seizures in severe pregnancy-induced hypertension (PIH) is unknown; however, it has been reported to both enhance and inhibit prostacyclin (PGI ) production by umbilical vein endothelial cells. Because PGI is decreased in patients with PIH, we tested the hypothesis that MgSO increases vasodilatory prostaglandins [PGI and prostaglandin (PG)E ] relative to vasoconstrictor eicosanoids [thromboxane (Tx)A and PGF aL] in patients with PIH. Methods: In 11 women with PIH (28-40 weeks' gestation), MgSO was administered i.v. as a 4-g loading dose, followed by 2 g/h continuous infusion. Plasma samples were obtained before and at 2 and 4 h of MgSO treatment. Main Outcome Measures: We measured the effects of i.v. MgSO on plasma 6-keto-PGF aL, TxB (metabolites of PGI and TxA , respectively), PGE , and PGF aL. Results: The control plasma 6-keto-PGF aL levels and 6-keto-PGF aL/TxB ratios averaged 22038 pg/mL and 1.410.35, respectively (SEM); they were decreased (P==0.03) after 2 h i.v. MgSO therapy to 7717 pg/mL and 0.470.13, respectively, and then rebounded by 4 h to 316122 pg/mL and 1.930.74, respectively. Although plasma TxB and PGE levels were unchanged by MgSO therapy (P>0.05), this treatment decreased (P==0.05) plasma PGF aL concentrations from 13125 pg/mL to 9021 pg/mL at 2 h and to 8716 pg/mL at 4 h. Conclusion: These in vivo data obtained from women with PIH are consistent with in vitro observations that MgSO may either inhibit or stimulate PGI production by endothelial cells. Additionally, MgSO infusion resulted in a modest but statically significant reduction in circulating levels of PGF aL. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. 4 2 2 4 2 2 2 2 4 4 4 1 2 2 2 2 2 1 1 2 4 2 2 4 2 4 2 4 2
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Andrews WW; Gant NF; Magness RR
  • Start Page

  • 71
  • End Page

  • 82
  • Volume

  • 13
  • Issue

  • 1