Alzheimer disease prevention: Focus on cardiovascular risk, not amyloid?

Academic Article


  • Autosomal dominant (early-onset) Alzheimer disease and the much more common sporadic Alzheimer disease share a common pathology but not necessarily a common pathophysiology. Common cardiovascular comorbidities are associated with increased risk for Alzheimer disease and offer opportunities for intervention. Class I evidence for prevention is extremely limited. The overall body of evidence suggests the best time to intervene is in midlife, not in old age.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 8000060
  • Author List

  • Geldmacher DS
  • Start Page

  • 689
  • End Page

  • 704
  • Volume

  • 77
  • Issue

  • 10