Priming in the brain, an immunologically privileged organ, elicits anti- tumor immunity

Academic Article

Abstract

  • A crucial question in the study of tumor neuro-immunology concerns the capacity of the central nervous system to initiate and execute an immune response. In a 100% fatal rat malignant glioma model, genetically modified tumors secreting INF-γ intracerebrally generate an immune response resulting in a substantial increase in survival time, tumor rejection and specific systemic immunity. Tumors modified to secrete IL-2 alone do not change the biologic behavior of transfected gliomas. INF-γ induces elevated expression of major-histocompatibility-complex-class-I and -class-II molecules in microglia throughout the brain and invokes enhanced tumor infiltration by CD4, CD8 and NK cells. These findings demonstrate successful immunization against a central-nervous-system tumor by direct priming in the brain with a live growth-competent tumor vaccine.
  • Published In

    Pubmed Id

  • 18314182
  • Author List

  • Fathallah-Shaykh HM; Gao W; Cho M; Herrera MA
  • Start Page

  • 266
  • End Page

  • 276
  • Volume

  • 75
  • Issue

  • 2