Acute therapies and disease-modifying therapies for multiple sclerosis



  • Multiple sclerosis (MS) is an inflammatory demyelinating CNS disease for which several immunomodulatory and immunosuppressive strategies have been shown to reduce evidence of disease activity and preserve neurological function. High-dose parenteral corticosteroid therapy speeds recovery from acute attacks of MS, including optic neuritis. Severe, corticosteroid-refractory attacks may respond to plasma exchange. Following a first-ever demyelinating event (clinically isolated syndrome), treatment with glatiramer acetate, intramuscular interferon ß-1a, or subcutaneous interferon ß-1b reduces the risk of the development of clinically definite MS over the subsequent 2–3 years.
  • Authors

    Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9780387885544
  • Pubmed Id

  • 9218869
  • Start Page

  • 273
  • End Page

  • 291