Severe sinus bradycardia after initiation of bupropion therapy: A probable drug-drug interaction with metoprolol

Academic Article


  • Bupropion is an increasingly prescribed agent to aid in smoking cessation. However it has important drug-drug interactions related to the cytochrome P450 system. One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • McCollum DL; Greene JL; McGuire DK
  • Start Page

  • 329
  • End Page

  • 330
  • Volume

  • 18
  • Issue

  • 4