Preparation of N-aryl-4-oxo-4H-1-benzothiopyran-2-acetamides from trilithiated acetoacetanilides and lithiated methyl thiosalicylate

Academic Article


  • Acetoacetanilide and substituted acetoacetanilides were trilithiated in excess lithium diisopropylamide, and the polylithiated intermediates were regioselectively condensed with lithiated methyl thiosalicylate, followed by acid cyclization to afford substituted N-aryl-4-oxo-4H-1-benzothiopyran-2-acetamides (thiochromone-2-acetamides).
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Angel AJ; Finefrock AE; French KL; Hurst DR; Williams AR; Rampey ME; Studer-Martinez SL; Beam CF
  • Start Page

  • 94
  • End Page

  • 97
  • Volume

  • 77
  • Issue

  • 1