Comparison of cilofungin and amphotericin B for therapy of murine candidiasis

Academic Article

Abstract

  • We compared the efficacies of cilofungin and amphotericin B treatment in a murine model of disseminated candidiasis. Three different dosages of each drug plus controls were evaluated. Statistically improved survival was noted only among mice treated with 1 mg of amphotericin B per kg of body weight (P < 0.05). While all amphotericin B regimens and the two lower-dosage cilofungin regimens significantly reduced yeast cell counts in kidneys compared with the controls, the amphotericin B-treated mice had a significantly higher percentage of sterile kidneys following therapy compared with those treated with cilofungin (P = 0.0001).
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 21714010
  • Author List

  • Smith KR; Lank KM; Cobbs CG; Cloud GA; Dismukes WE
  • Start Page

  • 1619
  • End Page

  • 1621
  • Volume

  • 34
  • Issue

  • 8