Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells

Academic Article


  • Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier. Copyright © 1982 AAAS.
  • Published In

  • Science  Journal
  • Digital Object Identifier (doi)

    Author List

  • Faustman D; Lacy P; Davie J; Hauptfeld V
  • Start Page

  • 157
  • End Page

  • 158
  • Volume

  • 217
  • Issue

  • 4555