A randomized, double-blind, placebo-controlled, multicenter study of rabbit ATG in the prophylaxis of acute rejection in lung transplantation

Academic Article

Abstract

  • ATG-Fresenius S (ATG-F) is a polyclonal anti-human-T-lymphocyte immunoglobulin preparation that has been clinically developed to prevent episodes of acute cellular rejection. This study evaluated the efficacy and safety of ATG-F at doses of 5 and 9 mg/kg versus placebo in adult recipients of a primary lung allograft. The primary efficacy composite end point was defined as death, graft loss, acute rejection and/or loss to follow-up within 12 months of transplantation. The interim analysis showed the ATG-F 5 mg/kg treatment to be inefficacious, and it would be impossible to enroll enough patients to power the study to show a difference between the 9 mg/kg arm and the placebo arm. Therefore, the main focus of the study shifted to the safety end points and a descriptive analysis of the primary end point. At 12 months posttransplant, the efficacy failure rate was not significantly different between the ATG-F 9 mg/kg group and the placebo group (40.2% vs. 36.7%, respectively). This large study did not demonstrate a significant reduction in acute cellular rejection, graft loss or death with single-dose induction therapy with ATG-F within the first year after lung transplantation. This randomized placebo-controlled trial of induction therapy in lung transplantation demonstrates that a single early posttransplant dose of ATG-Fresenius does not reduce acute cellular rejection, graft loss, or death within the first year of lung transplantation. © Copyright 2014 The American Society of Transplantation and the American Society of Transplant Surgeons.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Snell GI; Westall GP; Levvey BJ; Jaksch P; Keshavjee S; Hoopes CW; Ahya V; Mehta A; Trulock EP
  • Start Page

  • 1191
  • End Page

  • 1198
  • Volume

  • 14
  • Issue

  • 5