Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease

Academic Article


  • We have reported previously that striatal projection neurons are differentially affected in the course of Huntington's disease, and in a prior patient report we noted that differential loss of striatal projection neurons occurs also in patients with presymptomatic Huntington's disease. Striatal neurons projecting to the external segment of the globus pallidus or the substantia nigra show evident loss, whereas those projecting to the internal segment of the globus pallidus appear relatively spared at presymptomatic and early stages of symptomatic Huntington's disease. We now report similar findings in a second apparently presymptomatic Huntington's disease allele carrier. Copyright © 1992 American Neurological Association
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Albin RL; Reiner A; Anderson KD; Dure LS; Handelin B; Balfour R; Whetsell WO; Penney JB; Young AB
  • Start Page

  • 425
  • End Page

  • 430
  • Volume

  • 31
  • Issue

  • 4