Clinical effectiveness and safety of permissive hypercapnia

Academic Article


  • Experimental and clinical data indicate that ventilator strategies with permissive hypercapnia may reduce lung injury by a variety of mechanisms. Seven randomized controlled trials in preterm neonates suggest that permissive hypercapnia started early, before the initiation of mechanical ventilation (in conjunction with continuous positive airway pressure), followed by prolonged permissive hypercapnia if mechanical ventilation is needed is an alternative to early ventilation and surfactant. Permissive hypercapnia may improve pulmonary outcomes and survival. © 2012 Elsevier Inc.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Ryu J; Haddad G; Carlo WA
  • Start Page

  • 603
  • End Page

  • 612
  • Volume

  • 39
  • Issue

  • 3