Fetal Bladder-Neck Obstruction and Elevated Amniotic-Fluid Alpha Fetoprotein

Academic Article


  • To the Editor: The alpha-fetoprotein assay is a useful tool in the antenatal detection of neural-tube defects.1 Several other nonspecific abnormalities, including Turner's syndrome,2 omphalocele,3 esophageal atresia,4 congenital nephrotic syndrome,5 duodenal atresia6 and fetal death,7 have been associated with elevated alpha-fetoprotein levels in the amniotic fluid. Abnormal levels may also be caused by contamination of amniotic fluid by fetal blood. In the following case elevated amniotic-fluid alpha fetoprotein was associated with a fetal bladder-neck obstruction due to a posterior mucosal fold. A 37-year-old gravida 2, para 1, was referred for prenatal chromosome studies because of age. An amniocentesis at 16. © 1977, Massachusetts Medical Society. All rights reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Vinson PC; Goldenberg RL; Davis RO; Finley SC; Milunsky A; Chase TM; Nagendran SS
  • Start Page

  • 1351
  • Volume

  • 297
  • Issue

  • 24