Elevated CSF free kappa light chains correlate with disability prognosis in multiple sclerosis

Academic Article

Abstract

  • Elevated CSF free kappa light chains (FKLCs) may predict disability in multiple sclerosis (MS). We reviewed records of 57 patients with MS with 15-year median follow-up for correlations of disability and CSF FKLCs. Levels ≥ 1.53 μg/mL predicted progression to need for ambulatory assistance during follow-up (specificity 87.5%, positive predictive value 88.9%) or within 10 years (specificity 78.6%, positive predictive value 66.7%). ©2006AAN Enterprises, Inc.
  • Authors

    Published In

  • Neurology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Rinker JR; Trinkaus K; Cross AH
  • Start Page

  • 1288
  • End Page

  • 1290
  • Volume

  • 67
  • Issue

  • 7