Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

Academic Article

Abstract

  • Multiple sclerosis (MS) is a chronic inflammatory neurodegenerative disease, considered to be autoimmune in origin. Post-translational modification of central nervous system proteins, including glial fibrillary acidic protein (GFAP) and myelin basic protein (MBP), through citrullination of arginine residues, may lead to exposure of neoepitopes, triggering autoimmunity. Here we investigated the expression of citrullinated proteins in active MS lesions, MS normal appearing white matter and control brain white matter. We demonstrate increased citrullinated GFAP and MBP by immunohistochemistry and western blotting in areas of ongoing demyelination, suggesting a pivotal role for deimination of GFAP and MBP in MS pathogenesis MS. © 2014 Elsevier B.V.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Bradford CM; Ramos I; Cross AK; Haddock G; McQuaid S; Nicholas AP; Woodroofe MN
  • Start Page

  • 85
  • End Page

  • 95
  • Volume

  • 273
  • Issue

  • 1-2