Suppressor factor activity in cell mediated immune responses

Academic Article

Abstract

  • This discussion has focused on the characterization of mixed leucocyte reactions (MLR) suppressor factor, a soluble product of alloantigen-activated T cells which suppresses proliferative responses to alloantigens in vitro. This mediator shares similarities with an array of T cell factors in terms of molecular size, lack of identifiable immunoglobulin determinants, and in some cases, presence of determinants encoded by genes of the MHC. While these factors may exhibit differences in targets of activity, mechanisms of action and specific immunogenetic properties, we postulate that they represent a class of molecules produced by activated T cells which exert biologic activity in the regulation of immune responses.
  • Authors

    Author List

  • Solliday Rich S; Rich RR; Kastner DL
  • Start Page

  • 417
  • End Page

  • 425
  • Volume

  • 24
  • Issue

  • 4