Cadaveric orthotopic auxiliary split liver transplantation and kidney transplantation: An alternative for type 1 primary hyperoxaluria

Academic Article

Abstract

  • Liver transplantation (LTX) corrects the enzymatic defect responsible for type 1 primary hyperoxaluria (PH1). It has been advocated in combination with kidney transplantation (KTX) in patients with renal failure from PH1 because KTX alone can result in early graft loss. A 58-year-old male patient with PH1 on hemodialysis underwent resection of the left lateral segment of the liver followed by orthotopic auxiliary left lateral segment liver transplantation and kidney transplantation from a deceased donor. The serum oxalate dropped from 34.8 μmol/L before transplant to 3.6-8.3 in the first months posttransplant to < 1 μmol/L (normal range 0.4-3.0). One year after posttransplant, the patient has an iothalamate glomerular filtration rate of 58 ml/min. Orthotopic auxiliary LTX is an alternative to whole LTX in PH1. By using a split deceased donor liver, it does not deprive the donor pool and protects the recipient from liver failure in case of graft loss. Copyright © 2005 by Lippincott Williams & Wilkins.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 15668875
  • Author List

  • Onaca N; Sanchez EQ; Melton LB; Netto GJ; Glastad KA; Martin PA; Ueno T; Levy MF; Goldstein RM; Klintmalm GB
  • Start Page

  • 421
  • End Page

  • 424
  • Volume

  • 80
  • Issue

  • 3