Antibody Response to Herpes Simplex Virus Glycoprotein d: Effects of Acyclovir and Relation to Recurrence

Academic Article


  • We developed an enzyme-linked immunosorbent assay (ELISA) for measuring the antibody response to herpes simplex virus (HSV) glycoprotein D (gD). The ELISA was specific and more sensitive than immunoblotting techniques. Antibody to HSV gD was detected in 10of 12sera (geometric mean titer, 36.3) obtained from HSV-2-infected guinea pigs 14 days after intravaginal inoculation, and the titer increased to ⩾5,120 on day 60. Therapy with acyclovir delayed and diminished the antibody response to gD, although by day 60 the titers of antibody to gD in acyclovir-treated animals were not significantly different from those in controls. An increased titer of antibody to gD seemed to be associated with a reduced number of recurrent episodes and to a reduced number of days with recurrent lesions. © 1987 by The University of Chicago.
  • Digital Object Identifier (doi)

    Author List

  • Bernstein DI; Stanberry LR; Harrison CJ; Shukla R; Kappes JC; Myers MG
  • Start Page

  • 423
  • End Page

  • 429
  • Volume

  • 156
  • Issue

  • 3