Short communication: HIV type 1 escapes inactivation by saliva via rapid escape into oral epithelial cells

Academic Article

Abstract

  • Saliva contains anti-HIV-1 factors, which show unclear efficacy in thwarting mucosal infection. When incubated in fresh, unfractionated whole saliva, infectious HIV-1 IIIb and BaL (X4- and R5-tropic, respectively) persisted from 4 to at least 30min in a saliva concentration-dependent manner. In salivary supernatant for up to 6h, both infectious HIV-1 strains "escaped" into immortalized oral epithelial cells; infectious BaL showed selectively enhanced escape in the presence of saliva. Fluorescently labeled HIV-1 virus-like particles entered oral epithelial cells within minutes of exposure. Using a previously unrecognized mechanism, therefore, strains of HIV-1 escape inactivation by saliva via rapid uptake into oral epithelial cells. © Copyright 2012, Mary Ann Liebert, Inc.
  • Digital Object Identifier (doi)

    Author List

  • Dietrich EA; Gebhard KH; Fasching CE; Giacaman RA; Kappes JC; Ross KF; Herzberg MC
  • Start Page

  • 1574
  • End Page

  • 1578
  • Volume

  • 28
  • Issue

  • 12