Cyclotron Production of 99mTc using 100Mo2C targets

Academic Article


  • An investigative study of the 100Mo (p,2n)99mTc reaction on a medical cyclotron using 100Mo2C is reported. This is the first report of this compound being used as a target for this reaction. 100Mo2C, a refractory carbide with high thermal conductivity, properties which underscore its use on a cyclotron, was synthesized using 100MoO3. Its ease of oxidation back to 100MoO3 under air at elevated temperatures facilitates the use of thermo-chromatography, a high temperature gas phase separation technique for the separation and isolation of 99mTc. Activity yields for 99mTc averaged 84% of the calculated theoretical yields. Additionally, the percent recovery of MoO3, the precursor for Mo2C, was consistently high at 85% ensuring a good life cycle for this target material. The produced 99mTc was radio-chemically pure and easily labeled MDP for imaging purposes. © 2013 Elsevier Inc.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Richards VN; Mebrahtu E; Lapi SE
  • Start Page

  • 939
  • End Page

  • 945
  • Volume

  • 40
  • Issue

  • 7