The development of noninvasive imaging techniques using monoclonal antibodies (mAbs) is a quickly evolving field. Immuno-PET uses positron-emitting isotopes to track the localization of mAbs with excellent image quality. Procedures for labeling mAbs with 89Zr or 124I using good manufacturing procedures have been established, and therefore these radiopharmaceuticals are being investigated for clinical use. This short review will focus on immuno-PET with full mAbs using long-lived positron-emitting isotopes (89Zr and 124I) over the past 5 y and discuss their progress into clinical use. COPYRIGHT © 2013 by the Society of Nuclear Medicine and Molecular Imaging, Inc.