Costs and risks in the management of patients with gastric acid hypersecretion

Academic Article


  • Goals: To define both risks and costs of optimal care of patients with gastric acid hypersecretion. Background: The management of Zollinger-Ellison syndrome and other gastric acid hypersecretory disorders remains challenging. The optimal strategy for follow-up including gastric acid analysis, laboratory studies, and endoscopy is unknown but important given the potential complications from uncontrolled acid secretion. Study: Over the last 18 years, patients with gastric acid hypersecretory disorders have been followed prospectively with gastric acid analysis and endoscopy titrating oral lansoprazole and evaluating for complications. Protocol driven charges were calculated using the most recent information available. Results: After 1 year of treatment optimization, 19 of 67 patients had 43 relapses, (once only in 10 patients). Risk markers for relapse included: (1) antrectomy, 67% relapsed versus 21% in unoperated patients; (2) basal acid output >5
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Hirschowitz BI; Fineberg N; Wilcox CM; Mohnen J; Worthington J
  • Start Page

  • 28
  • End Page

  • 33
  • Volume

  • 44
  • Issue

  • 1