Alcohol consumption negates estrogen-mediated myocardial repair in ovariectomized mice by inhibiting endothelial progenitor cell mobilization and function

Academic Article

Abstract

  • Background: Estrogen supplementation enhances voluntary alcohol consumption in ovariectomized rodents. The effects of the enhanced alcohol consumption on post-infarct myocardial repair are unknown. Results: Ethanol-mediated suppression of endothelial progenitor cells produces diminished post-ischemic left ventricular function. Conclusion: Estrogen-induced increases in alcohol consumption negatively compete with the cardioprotective effects of estrogen. Significance: Alcohol consumption during estrogen replacement therapy must be observed closely. © 2013 by The American Society.
  • Digital Object Identifier (doi)

    Author List

  • Mackie AR; Krishnamurthy P; Verma SK; Thorne T; Ramirez V; Qin G; Abramova T; Hamada H; Losordo DW; Kishore R
  • Start Page

  • 18022
  • End Page

  • 18034
  • Volume

  • 288
  • Issue

  • 25