Chemical priming for spinal cord injury: A review of the literature part II-potential therapeutics

Academic Article


  • Introduction: Spinal cord injury is a complex cascade of reactions secondary to the initial mechanical trauma that puts into action the innate properties of the injured cells, the circulatory, inflammatory, and chemical status around them, into a non-permissive and destructive environment for neuronal function and regeneration. Priming means putting a cell, in a state of "arousal" towards better function. Priming can be mechanical as trauma is known to enhance activity in cells. Materials and methods: A comprehensive review of the literature was performed to better understand the possible chemical primers used for spinal cord injuries. Conclusions: Taken together, many studies have shown various promising results using the substances outlined herein for treating SCI. © 2010 Springer-Verlag.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Mortazavi MM; Verma K; Deep A; Esfahani FB; Pritchard PR; Tubbs RS; Theodore N
  • Start Page

  • 1307
  • End Page

  • 1316
  • Volume

  • 27
  • Issue

  • 8