Chiari I malformation and idiopathic growth hormone deficiency in siblings

Academic Article


  • Introduction: The authors report a case of three brothers. Two of these siblings presented with congenital growth hormone deficiency and Chiari I malformation. The third and younger brother has been found not to have growth hormone deficiency or the Chiari I malformation. Results: Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa has been determined to be altered in patients with Chiari I malformation and growth hormone deficiency. Conclusion: Our current case reports strengthen the association between these two pathological entities and are, to our knowledge, the first description of both defects in siblings. © Springer-Verlag 2006.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Murphy RL; Tubbs RS; Grabb PA; Oakes WJ
  • Start Page

  • 632
  • End Page

  • 634
  • Volume

  • 22
  • Issue

  • 6