Pharmacological therapy for acute spinal cord injury

Academic Article


  • Despite 4 prospective blinded randomized controlled trials investigating the effect of MP in acute SCI, there exists no Class I medical evidence of any beneficial effect.2,4,8,20 Two prospective Class II trials also failed to demonstrate the therapeutic efficacy of MP in SCI.14,29 In total, over 980 patients have received steroids for SCI and over 280 have participated as control subjects within the protocol of a prospective clinical trial-in which, universally, all primary comparisons to establish efficacy have been negative. A variety of Class III medical evidence has been published supporting the neuroprotective effect ofMPin SCI. © 2013 by the Congress of Neurological Surgeons.
  • Published In

  • Neurosurgery  Journal
  • Digital Object Identifier (doi)

    Author List

  • Hurlbert RJ; Hadley MN; Walters BC; Aarabi B; Dhall SS; Gelb DE; Rozzelle CJ; Ryken TC; Theodore N
  • Start Page

  • 93
  • End Page

  • 105
  • Volume

  • 72
  • Issue

  • SUPPL.2