Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis

Academic Article

Abstract

  • Using a rabbit model of postsurgical osteomyelitis, we demonstrate that incorporation of xylitol into polymethylmethacrylate (PMMA) bone cement enhances the elution of daptomycin under in vivo conditions. We also demonstrate that this can be correlated with an improved therapeutic outcome in the treatment of a chronic bone infection following surgical debridement. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Beenken KE; Bradney L; Bellamy W; Skinner RA; McLaren SG; Gruenwald MJ; Spencer HJ; Smith JK; Haggard WO; Smeltzer MS
  • Start Page

  • 5839
  • End Page

  • 5844
  • Volume

  • 56
  • Issue

  • 11