We report a case of simultaneous pancreas-kidney transplant, referred to us with an arteriovenous fistula (AVF) in the transplanted pancreas. The AVF was manifested by compromised functions of the transplanted pancreas. The patient was successfully treated with percutaneous transcatheter embolotherapy using Amplatzer Vascular Plug 2 (St. Jude Medical, Plymouth, MA), after the adequacy of the pancreatic transplant perfusion was ensured to avoid the risk of postembolization pancreatic infarction. There were no complications related to the procedure and the patient pancreatic functions and clinical status returned to baseline. Our case highlights a rare vascular complication related to pancreatic transplant that was managed by minimally invasive endovascular treatment. To our knowledge, the technique used in treatment of this case was not previously described in literature. © 2013 Springer Science+Business Media and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE).