© 2016 Kadivar et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Backgroun Breast cancer is a leading cause of cancer death among Hispanic women in the U.S., an mammography is the recommended screening for early diagnosing and preventing breas cancer. Several barriers exist to influence mammography utilization including poor healt literacy. However, it is unclear whether the effect of health literacy on mammography utilizatio is consistent between Hispanic women and non-Hispanic White women. The mai objective of this study was to examine association between functional health literacy an the receipt of mammography among Hispanic women compared to non-Hispanic Whit women in the U.S Method A cross-sectional design using participants engaged in the National Assessment of Adul Literacy. Study sample comprised of 4,249 Hispanic and non-Hispanic U.S.-born Whit women ≥ 40 years of age who completed the functional health literacy assessment Regression analyses were performed to test the association between health literacy an receipt of mammography. Among Hispanic women, analyses considered the influence o language-preference acculturation Result Equal percentages of Hispanic (59.3%) and non-Hispanic White (60.6%) women receive mammography. After adjusting for covariates, health literacy was positively associated wit receiving mammography among U.S.-born White women (? = 0.14, p<0.001), but negativel associated with mammography among Hispanic women (β =-0.13, p<0.001). Analyse stratified by acculturation status revealed that higher health literacy was associate with lower mammography among language-preference acculturated Hispanic women (β-0.48, p<0.001), yet an opposite result among less acculturated Hispanic women (β = 0.08 p<0.001) Conclusio Functional health literacy has different associations with mammography depending upo ethnicity. Language-preference acculturation may explain the differing association.