Molecular pathways and therapies in autosomal-dominant polycystic kidney disease

Academic Article

Abstract

  • © 2015 Int. Union Physiol. Sci./Am. Physiol. Soc. Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future clinical studies.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Saigusa T; Darwin Bell P
  • Start Page

  • 195
  • End Page

  • 207
  • Volume

  • 30
  • Issue

  • 3