Synthesis of QS-21-based immunoadjuvants

Academic Article

Abstract

  • Three structurally defined QS-21-based immune adjuvant candidates (2a-2c) have been synthesized. Application of the two-stage activation glycosylation approach utilizing allyl glycoside building blocks improved the synthetic accessibility of the new adjuvants. The efficient synthesis and establishment of the stand-alone adjuvanticity of the examined synthetic adjuvant (2b) open the door to the pursuit of a new series of structurally defined QS-saponin-based synthetic adjuvants. © 2013 American Chemical Society.
  • Digital Object Identifier (doi)

    Author List

  • Wang P; Dai Q; Thogaripally P; Zhang P; Michalek SM
  • Start Page

  • 11525
  • End Page

  • 11534
  • Volume

  • 78
  • Issue

  • 22