Objective: To investigate the unique contributions of social problem-solving abilities and social support in the prediction of aspects of caregiver adjustment. Study Design: Correlational procedures were used to determine the unique contributions of social problem-solving abilities and social support in the prediction of caregiver depression, health, and life satisfaction. Mediating factors were examined with correlational and regression analyses. Participants: Caregivers of individuals who had a stroke (20 African Americans and 20 Caucasians). Main Outcome Measures: The general health scale from the Short-Form Health Survey and measures of life satisfaction and depression. Results: Social support was the best predictor of caregiver life satisfaction. Perceived control over emotions when solving problems was the best predictor of caregiver depressive behavior and health. Social problem-solving abilities were associated with caregiver depressive behavior and health; social support did not mediate these relationships. Conclusions: Problem-solving interventions may be most appropriate for the treatment and prevention of caregiver depression and health problems. Social support programs may be indicated for caregiver life satisfaction.