L-tyrosine induces tyrosinase expression via a posttranscriptional mechanism

Academic Article


  • Exposure of hamster amelanotic melanoma cells to L-tyrosine caused a time-dependent increase of tyrosinase protein concentrations, tyrosinase activity and level of cell pigmentation. In contrast, Northern blot analysis using mouse tyrosinase cDNA showed a steady level of tyrosinase mRNA. Thus in hamster melanoma cells the stimulation of intracellular tyrosinase concentration by L-tyrosine is mediated mainly via a posttranscriptional mechanism. ¬© 1991 Birkh√§user Verlag.
  • Published In

  • Experientia  Journal
  • Digital Object Identifier (doi)

    Author List

  • Slominski A; Costantino R
  • Start Page

  • 721
  • End Page

  • 724
  • Volume

  • 47
  • Issue

  • 7