RNA polymerase: Chromosome domain boundary maker and regulator of supercoil density

Academic Article


  • Most bacterial chromosomes and plasmids are covalently closed circular molecules that are maintained in a dynamic supercoiled state. Average supercoil density differs significantly between Escherichia coli and Salmonella. Two related questions are: What protein(s) create supercoil domain boundaries in a bacterial chromosome? and How is supercoil density regulated in different bacterial species? RNA polymerase plays pivotal roles in both of these topological phenomena.
  • Author List

  • Higgins NP
  • Start Page

  • 138
  • End Page

  • 143
  • Volume

  • 22