Corticotropin-releasing hormone affects cytokine production in human HaCaT keratinocytes

Academic Article


  • CRH cutaneous expression is significantly enhanced after exposure to various stimuli (Physiol Rev 2000, 80;979-1020). We evaluated the effect of CRH on cytokine production in HaCaT keratinocytes, a cell line shown to express CRH receptors coupled to cAMP activation and calcium-dependent transmission pathways. It is demonstrated for the first time that exogenously added CRH stimulates production of IL-6 and IL-11. It also inhibits production of IL-1beta and does not affect TNF-alpha production. Our results indicate that CRH function(s) during cutaneous stress may be mediated by differential effects on cytokine production. © 2002 Elsevier Science Inc. All rights reserved.
  • Published In

  • Life Sciences  Journal
  • Digital Object Identifier (doi)

    Author List

  • Zbytek B; Mysliwski A; Slominski A; Wortsman J; Wei ET; Mysliwska J
  • Start Page

  • 1013
  • End Page

  • 1021
  • Volume

  • 70
  • Issue

  • 9