Dosage balance in gene regulation: Biological implications

Academic Article


  • Classical studies in genetics involving aneuploidy and ploidy comparisons and sex-determination mechanisms indicated a balance phenomenon such that changes of individual chromosomal dosage altered the phenotype more dramatically than changes in ploidy. Recent evidence suggests that a major contributor to this balance is the behavior of molecular complexes that function in various regulatory processes affecting gene expression. In this article, we discuss the potential contribution of regulatory balance to the control of quantitative traits, hybrid vigor, genome evolution and post-zygotic speciation mechanisms. © 2005 Elsevier Ltd. All rights reserved.
  • Published In

  • Trends in Genetics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Birchler JA; Riddle NC; Auger DL; Veitia RA
  • Start Page

  • 219
  • End Page

  • 226
  • Volume

  • 21
  • Issue

  • 4