Characterization of the serotype e polysaccharide antigen of Streptococcus mutans

Academic Article


  • The structure of the Streptococcus mutans serotype e polysaccharide was studied in order to determine the chemical basis of the immunological cross-reactions observed between it and the streptococcal group E polysaccharide. The chemical structure was established using methylation analysis, periodate oxidation, partial methanolysis and 13C NMR spectroscopy. The polysaccharide was found to consist of a polyrhamnose backbone of alternating 2- and 3-linked α-l-rhamnose units and sidechain β-d-glucosyl units linked to the 2-position of rhamnose units in the backbone. This structure of the oligosaccharide repeating unit of the S. mutans serotype e polysaccharide was identical to that of the group-specific polysaccharide of group E Streptococcus. Possible explanations for the previously reported differences in these two polysaccharides are discussed. © 1986.
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    Digital Object Identifier (doi)

    Author List

  • Pritchard DG; Gregory RL; Michalek SM; McGhee JR
  • Start Page

  • 141
  • End Page

  • 145
  • Volume

  • 23
  • Issue

  • 2