Oseltamivir dosing in premature infants

Academic Article

Abstract

  • We conducted a 2-sample pharmacokinetic study of oseltamivir in 12 premature infants. Oseltamivir 1 mg/kg/dose twice daily in infants <38 weeks postmenstrual age (n = 8) resulted in oseltamivir carboxylate exposure comparable to previously published pediatric data, which helps prospectively validate this regimen. Oseltamivir 3 mg/kg/dose once daily in premature infants >38 weeks postmenstrual age (born prematurely but chronologically past term, n = 4) resulted in similar oseltamivir and oseltamivir carboxylate exposure. Although these results suggest persistence of immature renal function in this subgroup, further pharmacokinetic/pharmacodynamic description is required to confirm the appropriateness of this regimen. © 2012 The Author.
  • Digital Object Identifier (doi)

    Author List

  • McPherson C; Warner B; Hunstad DA; Elward A; Acosta EP
  • Start Page

  • 847
  • End Page

  • 850
  • Volume

  • 206
  • Issue

  • 6